An innovative device could pave the way for more convenient diabetes monitoring.
A prototype sensor that measures glucose levels in saliva could eventually offer a simple, rapid, and painless way for people to monitor their diabetes, according to the King Abdullah University of Science & Technology (KAUST) researchers behind the technology.
Diabetes is a disease that occurs when the body cannot regulate its blood glucose levels. Raised glucose levels can lead to cardiovascular disease and other conditions, so it is vital that people with diabetes maintain their blood glucose at moderate levels.
People with diabetes have traditionally monitored their blood glucose using devices that analyze a drop of blood by pricking a finger several times a day. More recently, implanted sensors can provide continuous glucose monitoring without unpleasant pinpricks, but these devices can be less accurate for lower glucose levels and are not approved for children.
Professor Thomas Anthopoulos and Abhinav Sharma (pictured above) are now developing an array of transistor sensors that could simultaneously detect multiple metabolites in saliva. Credit: © 2023 KAUST; Anastasia Serin
Saliva as an Alternative to Blood Testing
A more convenient way to monitor glucose could be through testing saliva, which is correlated to blood glucose levels. However, glucose concentrations are much lower in saliva than in blood, which has made it difficult to measure accurately without sophisticated laboratory equipment.
The KAUST team has now created a highly sensitive glucose detector based on a thin-film transistor. These small, lightweight, and low-power devices could be suitable for mass production as inexpensive disposable sensors, says team member Abhinav Sharma. “An easy-to-use noninvasive glucose-measuring device using saliva as a medium could be life-changing for millions of patients worldwide,” he says.
How the Device Works
The transistor contains thin layers of the semiconductors indium oxide and zinc oxide, topped with the enzyme glucose oxidase. When a sample of saliva is placed on the sensor, the specific enzyme oxidizes any glucose present to produce D-gluconolactone and hydrogen peroxide. Electrical oxidation of the hydrogen peroxide then produces electrons that enter the semiconductor layers. That changes the current flowing through the semiconductors, and the size of this effect indicates the glucose concentration within the sample.
The researchers tested their device using human saliva samples that had different amounts of glucose added to them and also analyzed saliva from volunteers who had fasted before taking the tests (glucose levels in saliva may not correlate with blood glucose immediately after a meal).
