A new drug presents the world’s first treatment for Lipoprotein(a), a predominantly genetic type of cholesterol that elevates the risk of cardiac arrest or stroke.
Professor Stephen Nicholls, Director of the Victorian Heart Institute and Victorian Heart Hospital at Monash University, recently announced the development of a groundbreaking, world-first medication for Lipoprotein(a). This largely genetic form of cholesterol elevates the risk of heart attack and stroke.
High levels of Lipoprotein(a), known as Lp(a) or spoken as ‘LP little a’, impact one in five people globally with no approved treatment currently on the market.
The trial demonstrated the success of Muvalaplin – the first oral drug ever developed to target Lp(a) – effectively lowering levels by up to 65%. It works by disrupting the ability for Lp(a) to form in the body.
Professor Stephen Nicholls, renowned cardiologist and Director of Monash University’s Victorian Heart Institute and the Victorian Heart Hospital at Monash Health, led the landmark research and trial, recently presented at the European Society of Cardiology Congress in Amsterdam and published in JAMA.
Lp(a) is similar to LDL cholesterol, sometimes called ‘bad cholesterol’, but is more sticky, increasing the risk of blockages and blood clots in arteries.
Common LDL-lowering drugs such as statins don’t have the same lowering effect on Lp(a). Being largely genetic, Lp(a) is also difficult to control through diet, exercise, and other lifestyle changes.
Although Lp(a) was discovered nearly 60 years ago there still aren’t any widely accessible treatments available to lower levels and reduce cardiovascular risk.
Professor Nicholls said the global research industry has been working on a targeted solution to treat elevated Lp(a) for the past decade, but advancements so far have been in difficult to administer injection-based therapies that are not yet on the market.
“When it comes to treating high Lp(a), a known risk factor for cardiovascular disease, our clinicians currently have no effective tools in their kit,” Professor Nicholls said.
